Voriconazole is used to treat serious fungal or yeast infections, such as aspergillosis (fungal infection in the lungs), candidemia (fungal infection in the blood), esophageal candidiasis (candida esophagitis), or other fungal infections (infections in the skin, stomach, kidney, bladder, or wounds).
Voriconazole for injection is an azole antifungal medication used to treat various fungal infections. Here are some important details about it:
Indications and Usage:
It is indicated for use in the treatment of adults and pediatric patients aged 12 to 14 years weighing greater than or equal to 50 kg and those aged 15 years and older regardless of body weight with the following conditions:
Invasive aspergillosis: This serious fungal infection affects the lungs and other organs.
Candidemia in non-neutropenic patients and other deep tissue Candida infections.
Serious fungal infections caused by Scedosporium apiospermum and Fusarium species, including Fusarium solani, in patients intolerant of, or refractory to, other therapy1.
Dosage and Administration:
For adults:
Invasive Aspergillosis: An initial loading dose of 6 mg/kg every 12 hours for the first 24 hours, followed by a maintenance dose of 4 mg/kg every 12 hours.
Candidemia in non-neutropenics and other deep tissue Candida infections: A dosage of 3-4 mg/kg every 12 hours.
Scedosporiosis and Fusariosis: A dosage of 4 mg/kg every 12 hours.
Hepatic Impairment: Use half the maintenance dose in adult patients with mild to moderate hepatic impairment (Child-Pugh Class A and B).
Renal Impairment: Avoid intravenous administration in adult patients with moderate to severe renal impairment (creatinine clearance <50 mL/min).
For pediatric patients aged 12 to 14 years weighing greater than or equal to 50 kg and those aged 15 years and older regardless of body weight, use the adult dosage1.
Formulation:
Voriconazole for injection is supplied as a lyophilized white to off-white cake or powder containing 200 mg voriconazole and 3,200 mg of hydroxypropyl β-cyclodextrin (HPβCD). After reconstitution, it provides 10 mg/mL of voriconazole and 160 mg/mL of HPβCD1.
Administration:
Voriconazole injection is given as a slow infusion into a vein, over 1 to 2 hours. It is usually administered by injection only if the patient cannot take the medicine orally2.
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