Heparin Sodium Injection – Description
Generic Name: Heparin Sodium Injection
Dosage Form: Injectable Solution
Strengths Available: Varies (e.g., 1,000 IU/mL, 5,000 IU/mL, 10,000 IU/mL)
Route of Administration: Intravenous (IV) or Subcutaneous (SC)
Composition:
Each mL of solution contains:
Active Ingredient: Heparin Sodium (USP/BP/EP grade)
Excipients: Sodium chloride, Water for Injection, and stabilizers as needed
Mechanism of Action:
Heparin Sodium is an anticoagulant that inhibits thrombin and activated Factor Xa, preventing the formation of blood clots. It enhances the activity of antithrombin III, leading to prolonged clotting time.
Indications:
Prophylaxis and treatment of venous thromboembolism (VTE)
Prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE)
Acute coronary syndrome (ACS), unstable angina, myocardial infarction (MI)
Anticoagulation in extracorporeal circulation (e.g., during dialysis, cardiac surgery, or blood transfusion)
Dosage & Administration:
Dosage varies based on indication and patient condition.
Typically administered via IV infusion for immediate effect or SC injection for prolonged action.
Contraindications:
Active bleeding disorders (e.g., hemophilia, gastrointestinal bleeding)
Severe thrombocytopenia
History of heparin-induced thrombocytopenia (HIT)
Hypersensitivity to heparin or pork-derived products
Adverse Effects:
Bleeding complications (bruising, hemorrhage)
Heparin-induced thrombocytopenia (HIT)
Hypersensitivity reactions
Osteoporosis (with long-term use)
Storage Conditions:
Store at controlled room temperature (15-30°C)
Protect from light and freezing
Packaging:
Available in ampoules and vials of different strengths