Propofol Injectable Emulsion
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Description:
- Propofol injectable emulsion is a sterile, nonpyrogenic emulsion containing 10 mg/mL of propofol suitable for intravenous administration.
- The chemical name for propofol is 2,6-diisopropylphenol.
- It is formulated as a white, oil-in-water emulsion and contains additional components such as soybean oil, glycerol, egg lecithin, and disodium edetate.
- The emulsion is isotonic and has a pH of 7 to 8.51.
Pharmacology:
- Propofol induces anesthesia rapidly, with minimal excitation, usually within 40 seconds from the start of injection (the time for one arm-brain circulation).
- Its mechanism of action is not fully understood, but it is thought to positively modulate the inhibitory function of the neurotransmitter GABA through the ligand-gated GABAA receptors.
- Steady-state propofol blood concentrations are generally proportional to its pharmacodynamic properties2.
Safety Considerations:
- Strict aseptic technique must always be maintained during handling of propofol.
- Propofol injectable emulsion is a single access parenteral product (single patient infusion vial) containing disodium edetate (EDTA) to inhibit the rate of microbial growth for up to 12 hours in case of accidental extrinsic contamination.
- However, it is not an antimicrobially preserved product under USP standards, so contamination should be suspected and the product discarded if necessary.
- Reports exist of microbial contamination due to failure to use aseptic technique, leading to serious consequences.
- Propofol vials are never to be accessed more than once or used on more than one person1.
Remember to consult a healthcare professional for personalized advice regarding the use of Propofol Injectable Emulsion. If you have any further questions or need additional information, feel free to ask! 😊
Propofol Injectable Emulsion
Strengths
1%, 2%
Fill Volumes
10 ml, 20 ml, 50 ml
Container
Glass Vial
Use
Propofol is an intravenous anesthetic used for procedural sedation, during monitored anesthesia care, or as an induction agent for general anesthesia.
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