Abciximab is a chimeric (mouse-human) monoclonal antibody that targets the glycoprotein IIb/IIIa receptor on platelets. It is primarily used as an antiplatelet agent to prevent blood clots during and after percutaneous coronary interventions (PCI), such as angioplasty.
Mechanism of Action
Abciximab works by inhibiting platelet aggregation. It binds to the glycoprotein IIb/IIIa receptors on the surface of platelets, preventing them from clumping together and forming blood clots. This helps maintain blood flow in the coronary arteries and reduces the risk of ischemic complications during cardiac procedures.
Clinical Applications Abciximab
Abciximab is indicated for use in patients undergoing PCI, including those with unstable angina or those who have had a mild heart attack. It is often used in combination with other anticoagulants like aspirin and heparin to enhance its effectiveness.
Side Effects
Common side effects of abciximab include bleeding, including gastrointestinal hemorrhage, and thrombocytopenia (a drop in platelet count). It is important for patients to be monitored closely for any signs of excessive bleeding or adverse reactions.
Future Prospects
Research continues to explore the potential of abciximab in other cardiovascular conditions and its long-term effects on platelet function. Its success in reducing ischemic complications during PCI highlights the importance of targeted biologic therapies in cardiac care.
Abciximab represents a significant advancement in the prevention of blood clots during cardiac procedures, offering new hope to patients undergoing these life-saving interventions.
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